Yogen Saunthararajah Selected Research

Deoxycytidine

1/2021	A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
12/2017	Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen.
1/2017	5-aza-2',2'-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer.
7/2012	Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.

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Yogen Saunthararajah Research Topics

Disease

35	Neoplasms (Cancer) 01/2022 - 05/2002
17	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2021 - 08/2002
17	Sickle Cell Anemia (Hemoglobin S Disease) 01/2019 - 01/2003
13	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021 - 07/2004
12	Leukemia 01/2021 - 07/2004
5	Uveal melanoma 01/2019 - 01/2011
5	Cytopenia 02/2015 - 01/2000
4	Hemoglobinopathies 01/2021 - 10/2010
4	Thalassemia 03/2014 - 12/2003
3	Neutropenia 01/2021 - 11/2003
3	beta-Thalassemia (Cooley's Anemia) 10/2018 - 01/2003
3	Primary Myelofibrosis (Myelosclerosis) 02/2015 - 08/2012
2	Pancytopenia 01/2022 - 01/2000
2	Aplastic Anemia (Anemia, Hypoplastic) 01/2022 - 09/2002
2	Bone Marrow Failure Disorders 12/2021 - 08/2002
2	Disease Progression 10/2021 - 01/2019
2	Multiple Myeloma 05/2021 - 01/2021
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 02/2011
2	Myeloid Leukemia (Leukemia, Myelocytic) 01/2019 - 05/2014
2	Hemolysis 09/2017 - 04/2008
2	Colonic Neoplasms (Colon Cancer) 01/2017 - 05/2002
2	Neoplasm Metastasis (Metastasis) 01/2016 - 01/2015
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2013 - 07/2004
2	Refractory Anemia 10/2012 - 01/2000
2	Melanoma (Melanoma, Malignant) 09/2012 - 07/2012
2	Graft vs Host Disease (Graft-Versus-Host Disease) 02/2007 - 02/2004
1	Glioma (Gliomas) 11/2022
1	idiopathic Aplastic anemia 12/2021
1	Large Granular Lymphocytic Leukemia 09/2021
1	Kidney Neoplasms (Kidney Cancer) 01/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Lymphoma (Lymphomas) 01/2021
1	Ascites 01/2020
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Hepatocellular Carcinoma (Hepatoma) 11/2019
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 04/2019

Drug/Important Bio-Agent (IBA)

23	Decitabine FDA Link 09/2021 - 01/2003
13	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 09/2004
11	Azacitidine (5 Azacytidine)FDA Link 01/2021 - 01/2003
9	Pharmaceutical PreparationsIBA 12/2019 - 11/2007
9	Fetal Hemoglobin (Hemoglobin F)IBA 11/2018 - 01/2003
8	MethyltransferasesIBA 01/2021 - 01/2013
7	Transcription Factors (Transcription Factor)IBA 11/2022 - 02/2012
6	EnzymesIBA 11/2022 - 10/2012
6	TetrahydrouridineIBA 01/2021 - 07/2012
6	Biomarkers (Surrogate Marker)IBA 12/2019 - 01/2011
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2004
4	DeoxycytidineIBA 01/2021 - 07/2012
4	GlobinsIBA 01/2021 - 01/2003
4	Co-Repressor ProteinsIBA 01/2021 - 06/2011
4	Sickle HemoglobinIBA 01/2019 - 12/2003
4	Hemoglobins (Hemoglobin)IBA 10/2018 - 01/2000
4	Biological ProductsIBA 01/2018 - 01/2011
3	ChromatinIBA 11/2022 - 05/2007
3	RNA Splicing FactorsIBA 01/2021 - 10/2012
3	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2018 - 04/2003
3	Cytarabine (Cytosar-U)FDA LinkGeneric 02/2013 - 12/2010
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2003 - 01/2000
3	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 10/2003 - 01/2000
2	DioxygenasesIBA 01/2022 - 08/2012
2	AntigensIBA 12/2021 - 09/2012
2	RNA (Ribonucleic Acid)IBA 10/2021 - 05/2021
2	CytokinesIBA 05/2021 - 09/2012
2	Lenalidomide (CC 5013)FDA Link 01/2021 - 03/2015
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 08/2012
2	Cytidine DeaminaseIBA 01/2020 - 10/2012
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2020 - 08/2012
2	LigandsIBA 01/2019 - 07/2014
2	TransferasesIBA 01/2017 - 07/2012
2	CytidineIBA 02/2013 - 10/2012
2	Erythropoietin FDA Link 05/2011 - 01/2000
2	Silver Sulfadiazine (SSD)FDA LinkGeneric 09/2004 - 12/2003
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 01/2022
1	Thrombopoietin ReceptorsIBA 01/2022
1	eltrombopag FDA Link 01/2022
1	HLA Antigens (Human Leukocyte Antigens)IBA 12/2021
1	Protein Disulfide-IsomerasesIBA 05/2021
1	Immunoglobulins (Immunoglobulin)IBA 05/2021
1	Thioredoxin-Disulfide ReductaseIBA 01/2021
1	Naphazoline (All Clear)FDA LinkGeneric 01/2021
1	ProdrugsIBA 01/2021
1	pyrimidineIBA 01/2021
1	Gemcitabine FDA Link 01/2020
1	Histone Deacetylase InhibitorsIBA 01/2020
1	folfirinoxIBA 01/2020
1	Dihydroorotate DehydrogenaseIBA 01/2020
1	Lysine (L-Lysine)FDA Link 01/2020
1	130-nm albumin-bound paclitaxelIBA 01/2020
1	SirtuinsIBA 01/2020
1	Clofarabine (Clolar)FDA Link 11/2019
1	Immune Checkpoint InhibitorsIBA 04/2019
1	CC ChemokinesIBA 01/2019
1	ChemokinesIBA 01/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	Retinaldehyde (Retinal)IBA 10/2018

Therapy/Procedure

26	Therapeutics 11/2022 - 10/2007
4	Drug Therapy (Chemotherapy) 07/2014 - 02/2011
2	Transplantation 01/2019 - 09/2004
1	Cell Transplantation 01/2019